EP-1316: Clinical experience with intensity modulated radiation total marrow irradiation (IMTMI)
نویسندگان
چکیده
منابع مشابه
Feasibility study for linac-based intensity modulated total marrow irradiation.
Total body irradiation (TBI) is used as a preconditioning regimen prior to bone marrow transplant for treatment of hematologic malignancies. During TBI, large volumes of normal tissue are irradiated, and this can lead to toxicities, most significantly in the lungs. Intensity modulated total marrow irradiation (IMTMI) may be able to reduce these toxicities by directly targeting the bone marrow w...
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BACKGROUND The new TomoDirect™ modality offers a non-rotational option with discrete beam angles. We have investigated this mode for TBI with the intention to test the feasibility and to establish it as a clinical routine method. Special foci were directed onto treatment planning, dosimetric accuracy and practical aspects. PATIENTS AND METHODS TBI plans were calculated with TomoDirect™ for a ...
متن کاملA set cover approach to fast beam orientation optimization in intensity modulated radiation therapy for total marrow irradiation.
The beam orientation optimization (BOO) problem in intensity modulated radiation therapy (IMRT) treatment planning is a nonlinear problem, and existing methods to obtain solutions to the BOO problem are time consuming due to the complex nature of the objective function and size of the solution space. These issues become even more difficult in total marrow irradiation (TMI), where many more beam...
متن کاملTargeted total marrow irradiation using three-dimensional image-guided tomographic intensity-modulated radiation therapy: an alternative to standard total body irradiation.
Total body irradiation (TBI) is an important part of bone marrow transplantation conditioning regimens. In TBI, dose escalation is difficult, because of associated normal organ toxicities. A method to deliver a more targeted dose of TBI preferentially to sites of greatest tumor burden is needed to reduce the dose to normal organs, reduce toxicities, and permit dose escalation. The purpose of th...
متن کاملTotal body irradiation with volumetric modulated arc therapy: Dosimetric data and first clinical experience
BACKGROUND To implement total body irradiation (TBI) using volumetric modulated arc therapy (VMAT). We applied the Varian RapidArc™ software to calculate and optimize the dose distribution. Emphasis was placed on applying a homogenous dose to the PTV and on reducing the dose to the lungs. METHODS From July 2013 to July 2014 seven patients with leukaemia were planned and treated with a VMAT-ba...
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ژورنال
عنوان ژورنال: Radiotherapy and Oncology
سال: 2013
ISSN: 0167-8140
DOI: 10.1016/s0167-8140(15)33622-7